INK4a/ARF-dependent senescence upon persistent replication stress
نویسنده
چکیده
Rapid and transient protein acetylation changes in response to DNA damage Comment on: Bennetzen MV, et al. Cell Cycle 2013; 12:1688–95; PMID:23656789; http://dx.doi.org/10.4161/cc.24758 Stephanie Jungmichel and Melanie Blasius; The Novo Nordisk Foundation Center for Protein Research; University of Copenhagen; Copenhagen, Denmark; Danish Cancer Society Research Center; Copenhagen, Denmark; Email: [email protected] and [email protected]; http://dx.doi.org/10.4161/cc.25315
منابع مشابه
MSK1 triggers the expression of the INK4AB/ARF locus in oncogene-induced senescence
The tumor suppressor proteins p15(INK4B), p16(INK4A), and p14(ARF), encoded by the INK4AB/ARF locus, are crucial regulators of cellular senescence. The locus is epigenetically silenced by the repressive Polycomb complexes in growing cells but is activated in response to oncogenic stress. Here we show that the mitogen- and stress-activated kinase (MSK1) is up-regulated after RAF1 oncogenic stres...
متن کاملPolycomb Mediated Epigenetic Silencing and Replication Timing at the INK4a/ARF Locus during Senescence
BACKGROUND The INK4/ARF locus encodes three tumor suppressor genes (p15(Ink4b), Arf and p16(Ink4a)) and is frequently inactivated in a large number of human cancers. Mechanisms regulating INK4/ARF expression are not fully characterized. PRINCIPAL FINDINGS Here we show that in young proliferating embryonic fibroblasts (MEFs) the Polycomb Repressive Complex 2 (PRC2) member EZH2 together with PR...
متن کاملp16 in Melanocyte Senescence and Differentiation
Background: The Ink4a-Arf tumor suppressor locus encodes two growth inhibitors, p16 and Arf, both of which are also implicated as effectors in cellular senescence. Because human germline defects in the INK4A-ARF locus are associated with familial melanoma, melanocytes may have unusual INK4A-ARF functions or controls of cell senescence. Because senescence is believed to be an anticancer mechanis...
متن کاملExpression of Arf Tumor Suppressor in Spermatogonia Facilitates Meiotic Progression in Male Germ Cells
The mammalian Cdkn2a (Ink4a-Arf) locus encodes two tumor suppressor proteins (p16(Ink4a) and p19(Arf)) that respectively enforce the anti-proliferative functions of the retinoblastoma protein (Rb) and the p53 transcription factor in response to oncogenic stress. Although p19(Arf) is not normally detected in tissues of young adult mice, a notable exception occurs in the male germ line, where Arf...
متن کاملNdy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus.
The histone H3 demethylase Not dead yet-1 (Ndy1/KDM2B) is a physiological inhibitor of senescence. Here, we show that Ndy1 is down-regulated during senescence in mouse embryonic fibroblasts (MEFs) and that it represses the Ink4a/Arf locus. Ndy1 counteracts the senescence-associated down-regulation of Ezh2, a component of polycomb-repressive complex (PRC) 2, via a JmjC domain-dependent process l...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 12 شماره
صفحات -
تاریخ انتشار 2013